| 1. Round | 16/01/2005 | Atlas Guadalajara | - | Santos Laguna | 1:2 |  |
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| 2. Round | 23/01/2005 | Santos Laguna | - | Dorados de Sinaloa | 2:1 | ||||
| 3. Round | 30/01/2005 | CF América | - | Santos Laguna | 4:2 | ||||
| 4. Round | 06/02/2005 | Santos Laguna | - | UAG Tecos | 4:2 | |
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| 5. Round | 13/02/2005 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 6. Round | 19/02/2005 | Jaguares Chiapas | - | Santos Laguna | 2:0 | ||||
| 7. Round | 27/02/2005 | Santos Laguna | - | CF Monterrey | 3:1 | ||||
| 8. Round | 06/03/2005 | Club Necaxa | - | Santos Laguna | 4:2 | ||||
| 10. Round | 20/03/2005 | Deportivo Guadalajara | - | Santos Laguna | 5:1 | ||||
| 12. Round | 10/04/2005 | Atlante | - | Santos Laguna | 3:0 |
Argentina
Mexico