| 3. Round | 19/02/2022 | General Caballero DJLM | - | Tacuary | 2:0 |  |
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| 18. Round | 13/06/2022 | Club Nacional | - | Tacuary | 3:0 | ||||
| 19. Round | 19/06/2022 | Tacuary | - | Guaraní | 0:2 | |
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| 20. Round | 24/06/2022 | Guaireña FC | - | Tacuary | 0:0 | ||||
| 21. Round | 28/06/2022 | Tacuary | - | Sol de América | 2:2 | ||||
| 22. Round | 02/07/2022 | Cerro Porteño | - | Tacuary | 1:0 |
Paraguay