| Group F | 23/04/2021 | Libertad | - | Palestino | 2:0 | ||||
| Group F | 30/04/2021 | Newell's Old Boys | - | Libertad | 1:3 | ||||
| Group F | 06/05/2021 | Libertad | - | Atlético Goianiense | 1:2 | ||||
| Group F | 19/05/2021 | Atlético Goianiense | - | Libertad | 0:0 |  |
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| Group F | 25/05/2021 | Palestino | - | Libertad | 1:2 |  |
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| Round of 16 | 15/07/2021 | Atlético Junior | - | Libertad | 3:4 | |
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| Round of 16 | 22/07/2021 | Libertad | - | Atlético Junior | 0:1 | ||||
| Quarter-finals | 13/08/2021 | Santos FC | - | Libertad | 2:1 | ||||
| Quarter-finals | 20/08/2021 | Libertad | - | Santos FC | 1:0 | |
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| Semi-finals | 22/09/2021 | Red Bull Bragantino | - | Libertad | 2:0 | ||||
| Semi-finals | 29/09/2021 | Libertad | - | Red Bull Bragantino | 1:3 |
Paraguay