| 1. Round | 07/02/2021 | Club Olimpia | - | Libertad | 0:1 | ||||
| 5. Round | 01/03/2021 | Libertad | - | River Plate | 2:1 | ||||
| 6. Round | 05/03/2021 | 12 de Octubre de Itauguá | - | Libertad | 2:1 |  |
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| 8. Round | 13/03/2021 | Sol de América | - | Libertad | 0:2 | |
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| 9. Round | 22/03/2021 | Libertad | - | Sportivo Luqueño | 2:0 | |
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| 7. Round | 29/03/2021 | Libertad | - | Guaraní | 1:1 | ||||
| 10. Round | 04/04/2021 | Libertad | - | Club Olimpia | 0:1 | ||||
| 16. Round | 17/05/2021 | Guaraní | - | Libertad | 1:6 | ||||
| 17. Round | 22/05/2021 | Libertad | - | Sol de América | 1:2 |
Paraguay