| 1. Round | 16/01/2010 | Jaguares Chiapas | - | Cruz Azul | 0:1 |  |
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| 8. Round | 28/02/2010 | Puebla FC | - | Jaguares Chiapas | 3:3 |  |
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| 9. Round | 06/03/2010 | Jaguares Chiapas | - | Deportivo Guadalajara | 4:0 | ||||
| 10. Round | 13/03/2010 | Jaguares Chiapas | - | Club San Luis | 1:1 | ||||
| 11. Round | 21/03/2010 | Pumas UNAM | - | Jaguares Chiapas | 2:0 | ||||
| 12. Round | 27/03/2010 | Jaguares Chiapas | - | CF Monterrey | 1:1 | |
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| 13. Round | 04/04/2010 | Santos Laguna | - | Jaguares Chiapas | 0:3 | ||||
| 14. Round | 10/04/2010 | Jaguares Chiapas | - | CF América | 1:3 | ||||
| 15. Round | 15/04/2010 | Monarcas Morelia | - | Jaguares Chiapas | 1:2 | |
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| 16. Round | 17/04/2010 | Jaguares Chiapas | - | Indios Juárez | 1:0 | ||||
| 17. Round | 25/04/2010 | Atlas Guadalajara | - | Jaguares Chiapas | 1:1 |
Mexico