| 4. Round | 20/08/2011 | Club Olimpia | - | General Caballero ZC | 2:1 | ||||
| 5. Round | 28/08/2011 | General Caballero ZC | - | Guaraní | 2:0 | ||||
| 6. Round | 03/09/2011 | 3 de Febrero | - | General Caballero ZC | 5:2 |  |
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| 8. Round | 18/09/2011 | General Caballero ZC | - | Club Rubio Ñu | 0:1 | ||||
| 10. Round | 28/09/2011 | General Caballero ZC | - | Cerro Porteño | 2:4 | |
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| 11. Round | 02/10/2011 | Sportivo Luqueño | - | General Caballero ZC | 1:4 | |
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| 12. Round | 16/10/2011 | Independiente CG | - | General Caballero ZC | 1:1 | |
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| 13. Round | 23/10/2011 | General Caballero ZC | - | Club Nacional | 2:0 | |
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| 14. Round | 30/10/2011 | Tacuary | - | General Caballero ZC | 4:0 | |
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| 15. Round | 05/11/2011 | General Caballero ZC | - | Club Olimpia | 1:2 | ||||
| 16. Round | 16/11/2011 | Guaraní | - | General Caballero ZC | 1:2 | ||||
| 17. Round | 20/11/2011 | General Caballero ZC | - | 3 de Febrero | 3:7 | |
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| 19. Round | 30/11/2011 | Club Rubio Ñu | - | General Caballero ZC | 0:2 | |
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| 20. Round | 04/12/2011 | General Caballero ZC | - | Sol de América | 1:2 | |
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| 21. Round | 11/12/2011 | Cerro Porteño | - | General Caballero ZC | 5:1 | ||||
| 22. Round | 17/12/2011 | General Caballero ZC | - | Sportivo Luqueño | 2:1 | |
Paraguay