| 1. Round | 08/01/2022 | Cruz Azul [U20] | - | Club Tijuana [U20] | 0:1 |  |
|||
| 2. Round | 15/01/2022 | Club Tijuana [U20] | - | Club León [U20] | 1:2 | ||||
| 4. Round | 05/02/2022 | Club Tijuana [U20] | - | Pumas UNAM [U20] | 1:1 | ||||
| 11. Round | 18/03/2022 | Club Tijuana [U20] | - | FC Juárez [U20] | 1:1 | ||||
| 12. Round | 03/04/2022 | UANL Tigres [U20] | - | Club Tijuana [U20] | 1:2 | |
|||
| 9. Round | 06/04/2022 | Club Tijuana [U20] | - | Atlético San Luis [U20] | 2:1 | ||||
| 13. Round | 11/04/2022 | CF Pachuca [U20] | - | Club Tijuana [U20] | 0:0 | ||||
| 14. Round | 15/04/2022 | Club Tijuana [U20] | - | CF América [U20] | 4:0 | |
|||
| 15. Round | 19/04/2022 | Deportivo Guadalajara [U20] | - | Club Tijuana [U20] | 1:1 | ||||
| 16. Round | 24/04/2022 | Club Tijuana [U20] | - | Gallos Blancos [U20] | 1:0 | ||||
| 17. Round | 30/04/2022 | CF Monterrey [U20] | - | Club Tijuana [U20] | 3:0 |
Mexico