 |
 |
|
|
| 04/03/2022 | 15:00 | Club Necaxa | - | Deportivo Toluca | 1:2 (0:1) | |
| 16:00 | FC Juárez | - | Club León | 0:1 (0:1) | ||
| 05/03/2022 | 15:00 | Gallos Blancos | - | Atlas Guadalajara | 0:1 (0:1) | |
| 15:00 | CF Monterrey | - | CF América | 3:2 (1:0) | ||
| 15:00 | Cruz Azul | - | Puebla FC | 3:0 (1:0) | ||
| 15:00 | Deportivo Guadalajara | - | Santos Laguna | 0:0 (0:0) | ||
| 27/03/2022 | 15:00 | Pumas UNAM | - | Mazatlán FC | 3:0 (2:0) | |
| 06/04/2022 | 21:45 | Club Tijuana | - | Atlético San Luis | 2:1 (1:1) | |
| 07/04/2022 | 15:00 | CF Pachuca | - | UANL Tigres | 2:0 (1:0) |
| » Tables | Home | Away | First round | Second round |
| # | Team | M. | W | D | L | goals | Dif. | Pt. | |
|---|---|---|---|---|---|---|---|---|---|
| 1 |
|
CF Pachuca | 9 | 7 | 0 | 2 | 20:11 | 9 | 21 |
| 2 |
|
Club León | 9 | 6 | 1 | 2 | 18:10 | 8 | 19 |
| 3 |
|
Club Tijuana | 9 | 6 | 1 | 2 | 14:9 | 5 | 19 |
| 4 |
|
UANL Tigres | 9 | 5 | 2 | 2 | 18:10 | 8 | 17 |
| 5 |
|
Deportivo Toluca | 9 | 5 | 2 | 2 | 16:11 | 5 | 17 |
| 6 |
|
Deportivo Guadalajara | 9 | 5 | 2 | 2 | 10:8 | 2 | 17 |
| 7 |
|
Atlético San Luis | 9 | 5 | 1 | 3 | 22:12 | 10 | 16 |
| 8 |
|
Pumas UNAM | 9 | 4 | 3 | 2 | 11:7 | 4 | 15 |
| 9 |
|
CF América | 9 | 4 | 1 | 4 | 15:10 | 5 | 13 |
| 10 |
|
CF Monterrey | 9 | 3 | 3 | 3 | 10:15 | -5 | 12 |
| 11 |
|
Santos Laguna | 9 | 3 | 2 | 4 | 9:14 | -5 | 11 |
| 12 |
|
Cruz Azul | 9 | 2 | 4 | 3 | 10:9 | 1 | 10 |
| 13 |
|
Club Necaxa | 9 | 3 | 1 | 5 | 13:14 | -1 | 10 |
| 14 |
|
Atlas Guadalajara | 9 | 2 | 2 | 5 | 7:14 | -7 | 8 |
| 15 |
|
Mazatlán FC | 9 | 2 | 1 | 6 | 8:16 | -8 | 7 |
| 16 |
|
Puebla FC | 9 | 2 | 1 | 6 | 10:20 | -10 | 7 |
| 17 |
|
FC Juárez | 9 | 1 | 2 | 6 | 8:21 | -13 | 5 |
| 18 |
|
Gallos Blancos | 9 | 0 | 3 | 6 | 1:9 | -8 | 3 |
| Playoffs |
