| 1. Round | 19/01/2008 | CF Monterrey | - | Club Necaxa | 1:1 | ||||
| 2. Round | 27/01/2008 | Puebla FC | - | CF Monterrey | 1:1 |  |
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| 3. Round | 02/02/2008 | CF Monterrey | - | Jaguares Chiapas | 0:0 | ||||
| 4. Round | 10/02/2008 | Pumas UNAM | - | CF Monterrey | 2:1 | |
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| 5. Round | 14/02/2008 | CF Monterrey | - | UAG Tecos | 3:0 | |
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| 6. Round | 17/02/2008 | Monarcas Morelia | - | CF Monterrey | 0:1 | |
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| 7. Round | 24/02/2008 | CF Monterrey | - | Atlas Guadalajara | 1:1 | ||||
| 8. Round | 02/03/2008 | Santos Laguna | - | CF Monterrey | 2:0 | |
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| 9. Round | 08/03/2008 | CF Monterrey | - | UANL Tigres | 2:3 | ||||
| 10. Round | 15/03/2008 | Club San Luis | - | CF Monterrey | 3:1 | ||||
| 11. Round | 22/03/2008 | CF Monterrey | - | Cruz Azul | 3:2 | |
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| 13. Round | 06/04/2008 | CF Monterrey | - | Veracruz (old) | 7:2 | |
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| 14. Round | 13/04/2008 | CF Pachuca | - | CF Monterrey | 1:1 | ||||
| 15. Round | 19/04/2008 | CF Monterrey | - | Deportivo Guadalajara | 1:0 | |
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| 16. Round | 27/04/2008 | Atlante | - | CF Monterrey | 2:3 | |
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| 17. Round | 04/05/2008 | CF América | - | CF Monterrey | 1:0 |
Chile