| 1. Round | 27/07/2008 | Puebla FC | - | CF Monterrey | 2:2 | ||||
| 2. Round | 02/08/2008 | CF Monterrey | - | Indios Juárez | 2:0 | ||||
| 3. Round | 10/08/2008 | Deportivo Guadalajara | - | CF Monterrey | 1:1 |  |
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| 4. Round | 17/08/2008 | CF Monterrey | - | UAG Tecos | 2:4 | ||||
| 5. Round | 23/08/2008 | Cruz Azul | - | CF Monterrey | 3:2 |  |
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| 6. Round | 28/08/2008 | Club Necaxa | - | CF Monterrey | 0:1 | |
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| 7. Round | 30/08/2008 | CF Monterrey | - | Santos Laguna | 2:0 | |
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| 8. Round | 14/09/2008 | Deportivo Toluca | - | CF Monterrey | 0:0 | ||||
| 9. Round | 20/09/2008 | CF Monterrey | - | Monarcas Morelia | 0:4 | ||||
| 10. Round | 28/09/2008 | CF Pachuca | - | CF Monterrey | 2:1 | ||||
| 13. Round | 18/10/2008 | CF Monterrey | - | UANL Tigres | 1:4 | |
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| 14. Round | 25/10/2008 | Club San Luis | - | CF Monterrey | 2:0 | ||||
| 15. Round | 01/11/2008 | CF Monterrey | - | Atlante | 2:1 | |
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| 16. Round | 09/11/2008 | CF América | - | CF Monterrey | 1:0 | ||||
| 17. Round | 15/11/2008 | CF Monterrey | - | Pumas UNAM | 1:0 | |
Chile