| 1. Round | 13/03/2022 | Colorado Springs Switchbacks | - | Orange County SC | 2:1 | ||||
| 1. Round | 20/03/2022 | Orange County SC | - | Rio Grande Valley FC | 2:1 | ||||
| 1. Round | 26/03/2022 | New Mexico United | - | Orange County SC | 1:1 | ||||
| 2. Round | 10/04/2022 | Orange County SC | - | San Antonio FC | 0:1 | ||||
| 2. Round | 17/04/2022 | Orange County SC | - | Sacramento Republic | 1:1 | ||||
| 2. Round | 24/04/2022 | Indy Eleven | - | Orange County SC | 3:1 | ||||
| 3. Round | 01/05/2022 | Rio Grande Valley FC | - | Orange County SC | 1:2 | ||||
| 3. Round | 14/05/2022 | Orange County SC | - | FC Tulsa | 5:1 | ||||
| 3. Round | 22/05/2022 | Orange County SC | - | El Paso Locomotive | 2:2 |  |
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| 3. Round | 28/05/2022 | Atlanta United II | - | Orange County SC | 0:0 | ||||
| 4. Round | 02/06/2022 | Oakland Roots | - | Orange County SC | 3:2 | |
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| 4. Round | 05/06/2022 | Orange County SC | - | New Mexico United | 1:2 |
USA