| 1. Round | 23/02/2025 | Inter Miami CF | - | New York City FC | 2:2 | ||||
| 2. Round | 03/03/2025 | Houston Dynamo | - | Inter Miami CF | 1:4 |  |
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| 3. Round | 09/03/2025 | Inter Miami CF | - | Charlotte FC | 1:0 | ||||
| 6. Round | 29/03/2025 | Inter Miami CF | - | Philadelphia Union | 2:1 | ||||
| 7. Round | 07/04/2025 | Inter Miami CF | - | Toronto FC | 1:1 | ||||
| 10. Round | 27/04/2025 | Inter Miami CF | - | FC Dallas | 3:4 | ||||
| 12. Round | 10/05/2025 | Minnesota United FC | - | Inter Miami CF | 4:1 | ||||
| 14. Round | 19/05/2025 | Inter Miami CF | - | Orlando City | 0:3 | ||||
| 15. Round | 25/05/2025 | Philadelphia Union | - | Inter Miami CF | 3:3 |  |
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| 16. Round | 29/05/2025 | Inter Miami CF | - | CF Montréal | 4:2 | ||||
| 17. Round | 01/06/2025 | Inter Miami CF | - | Columbus Crew | 5:1 |
USA