| 1. Round | 23/02/2025 | St. Louis City SC | - | Colorado Rapids | 0:0 | ||||
| 2. Round | 02/03/2025 | Colorado Rapids | - | FC Dallas | 3:3 | ||||
| 3. Round | 09/03/2025 | Austin FC | - | Colorado Rapids | 0:1 | ||||
| 5. Round | 23/03/2025 | Colorado Rapids | - | Portland Timbers | 0:3 | ||||
| 6. Round | 29/03/2025 | Colorado Rapids | - | Charlotte FC | 2:0 | ||||
| 7. Round | 06/04/2025 | Vancouver Whitecaps | - | Colorado Rapids | 2:0 | ||||
| 8. Round | 13/04/2025 | Colorado Rapids | - | San Diego FC | 3:2 | ||||
| 10. Round | 27/04/2025 | Colorado Rapids | - | Seattle Sounders | 1:1 | ||||
| 13. Round | 15/05/2025 | San Diego FC | - | Colorado Rapids | 2:0 | ||||
| 15. Round | 25/05/2025 | Colorado Rapids | - | St. Louis City SC | 1:0 | ||||
| 16. Round | 29/05/2025 | Portland Timbers | - | Colorado Rapids | 2:1 |
USA