| 2. Round | 23/01/2022 | Lobos ULMX | - | Yalmakan FC | 0:1 | ||||
| 3. Round | 30/01/2022 | Lobos ULMX | - | Inter Playa | 1:4 | ||||
| 4. Round | 07/02/2022 | Reboceros de La Piedad | - | Lobos ULMX | 1:2 | ||||
| 5. Round | 13/02/2022 | Lobos ULMX | - | Deportivo Dongu | 2:0 |  |
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| 8. Round | 05/03/2022 | Escorpiones | - | Lobos ULMX | 0:1 | ||||
| 9. Round | 13/03/2022 | Lobos ULMX | - | Cafetaleros de Chiapas | 0:0 | |
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| 11. Round | 27/03/2022 | Lobos ULMX | - | Inter de Querétaro | 0:0 | ||||
| 13. Round | 10/04/2022 | Lobos ULMX | - | Leviatán FC | 1:0 |
Mexico