9. Round | 20/09/2021 | Guaireña FC | - | Sportivo Luqueño | 1:2 | ||||
10. Round | 27/09/2021 | Guaireña FC | - | Libertad | 2:1 | ||||
11. Round | 03/10/2021 | River Plate | - | Guaireña FC | 1:1 | ||||
12. Round | 18/10/2021 | Guaireña FC | - | Club Olimpia | 0:2 | ||||
13. Round | 25/10/2021 | Guaireña FC | - | Cerro Porteño | 0:2 |