| 1. Round | 12/04/2021 | Universidad de Concepción | - | Santiago Morning | 3:3 |  |
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| 3. Round | 26/04/2021 | Santiago Morning | - | Santa Cruz | 1:3 | |
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| 4. Round | 03/05/2021 | Deportes Copiapó | - | Santiago Morning | 2:2 | ||||
| 5. Round | 10/05/2021 | Santiago Morning | - | San Marcos | 3:0 | ||||
| 7. Round | 24/05/2021 | Santiago Morning | - | Rangers | 0:0 | ||||
| 17. Round | 27/08/2021 | CD Magallanes | - | Santiago Morning | 0:1 | ||||
| 20. Round | 16/09/2021 | San Marcos | - | Santiago Morning | 4:0 | ||||
| 21. Round | 22/09/2021 | Santiago Morning | - | Cobreloa | 2:1 | |
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| 24. Round | 09/10/2021 | Coquimbo Unido | - | Santiago Morning | 2:1 | ||||
| 25. Round | 13/10/2021 | Santiago Morning | - | Barnechea | 2:0 | ||||
| 26. Round | 20/10/2021 | San Luis | - | Santiago Morning | 2:2 | ||||
| 27. Round | 25/10/2021 | Santiago Morning | - | Deportes Iquique | 1:0 | ||||
| 8. Round | 09/11/2021 | Fernández Vial | - | Santiago Morning | 0:0 | |
Chile