| 1. Round | 16/10/2020 | General Díaz | - | San Lorenzo | 0:1 | ||||
| 2. Round | 25/10/2020 | San Lorenzo | - | Club Nacional | 1:1 | ||||
| 3. Round | 01/11/2020 | Club Olimpia | - | San Lorenzo | 3:1 | ||||
| 4. Round | 06/11/2020 | 12 de Octubre de Itauguá | - | San Lorenzo | 0:1 | ||||
| 6. Round | 16/11/2020 | Guaraní | - | San Lorenzo | 2:1 |  |
|||
| 7. Round | 20/11/2020 | San Lorenzo | - | Libertad | 2:2 | ||||
| 8. Round | 27/11/2020 | Guaireña FC | - | San Lorenzo | 2:2 | |
|||
| 9. Round | 06/12/2020 | San Lorenzo | - | Sol de América | 2:2 |  |
|||
| 10. Round | 13/12/2020 | Cerro Porteño | - | San Lorenzo | 1:1 | ||||
| 11. Round | 18/12/2020 | San Lorenzo | - | River Plate | 0:0 |
Paraguay