| 1. Round | 26/07/2021 | Cruz Azul [U20] | - | Mazatlán FC [U20] | 1:1 | ||||
| 4. Round | 14/08/2021 | Club León [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 5. Round | 17/08/2021 | Deportivo Toluca [U20] | - | Mazatlán FC [U20] | 3:1 | ||||
| 6. Round | 20/08/2021 | Mazatlán FC [U20] | - | UANL Tigres [U20] | 3:2 | ||||
| 7. Round | 27/08/2021 | Mazatlán FC [U20] | - | Atlético San Luis [U20] | 3:1 | ||||
| 8. Round | 11/09/2021 | CF América [U20] | - | Mazatlán FC [U20] | 3:0 | ||||
| 9. Round | 18/09/2021 | Mazatlán FC [U20] | - | Pumas UNAM [U20] | 2:1 | ||||
| 10. Round | 24/09/2021 | Club Tijuana [U20] | - | Mazatlán FC [U20] | 3:5 | ||||
| 11. Round | 28/09/2021 | Mazatlán FC [U20] | - | FC Juárez [U20] | 2:2 | ||||
| 12. Round | 02/10/2021 | Santos Laguna [U20] | - | Mazatlán FC [U20] | 4:2 |
Mexico