| 1. Round | 18/03/2021 | Liga de Portoviejo | - | Guayaquil SC | 1:3 | ||||
| 5. Round | 15/04/2021 | Guayaquil SC | - | El Nacional | 2:1 | ||||
| 10. Round | 28/05/2021 | Cumbayá | - | Guayaquil SC | 2:1 | ||||
| 18. Round | 27/06/2021 | Guayaquil SC | - | Liga de Portoviejo | 2:1 | ||||
| 20. Round | 08/07/2021 | Guayaquil SC | - | El Nacional | 3:1 | ||||
| 23. Round | 18/07/2021 | Guayaquil SC | - | Cumbayá | 1:2 |  |
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| 24. Round | 22/07/2021 | Liga de Portoviejo | - | Guayaquil SC | 2:0 | ||||
| 25. Round | 29/07/2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | ||||
| 26. Round | 04/08/2021 | América de Quito | - | Guayaquil SC | 2:0 |
Uruguay