| 2. Round | 08/08/2003 | Real San Luis | - | Puebla FC | 4:0 | ||||
| 3. Round | 16/08/2003 | Puebla FC | - | Santos Laguna | 1:1 | ||||
| 4. Round | 23/08/2003 | Atlante | - | Puebla FC | 3:0 | ||||
| 1. Round | 26/08/2003 | Puebla FC | - | Atlas Guadalajara | 1:1 |  |
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| 5. Round | 30/08/2003 | Puebla FC | - | Jaguares Chiapas | 4:1 | |
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| 6. Round | 06/09/2003 | CF Pachuca | - | Puebla FC | 0:2 | |
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| 7. Round | 13/09/2003 | Puebla FC | - | Monarcas Morelia | 4:2 | |
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| 8. Round | 20/09/2003 | Gallos Blancos (old) | - | Puebla FC | 0:2 | ||||
| 9. Round | 23/09/2003 | Puebla FC | - | UANL Tigres | 0:1 | ||||
| 10. Round | 27/09/2003 | Deportivo Toluca | - | Puebla FC | 0:0 | ||||
| 11. Round | 04/10/2003 | Puebla FC | - | Deportivo Guadalajara | 1:1 | |
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| 12. Round | 10/10/2003 | Club Necaxa | - | Puebla FC | 1:0 | ||||
| 13. Round | 18/10/2003 | Club Irapuato | - | Puebla FC | 3:1 | ||||
| 14. Round | 21/10/2003 | Puebla FC | - | Pumas UNAM | 1:1 | ||||
| 15. Round | 24/10/2003 | Cruz Azul | - | Puebla FC | 1:0 | ||||
| 16. Round | 01/11/2003 | Puebla FC | - | Veracruz (old) | 3:4 | |
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| 17. Round | 08/11/2003 | UAG Tecos | - | Puebla FC | 2:1 | ||||
| 18. Round | 12/11/2003 | Puebla FC | - | CF Monterrey | 1:0 | ||||
| 19. Round | 21/11/2003 | CF América | - | Puebla FC | 4:1 |
Chile