| 1. Round | 16/05/2021 | Deportivo Maldonado | - | Liverpool | 2:4 |  |
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| 2. Round | 24/05/2021 | River Plate | - | Liverpool | 3:2 | |
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| 3. Round | 29/05/2021 | Liverpool | - | Cerro Largo | 3:0 | ||||
| 5. Round | 11/06/2021 | Liverpool | - | Sud América | 5:0 | |
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| 6. Round | 17/06/2021 | Plaza Colonia | - | Liverpool | 2:1 | |
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| 7. Round | 22/06/2021 | Liverpool | - | Fénix | 5:2 | |
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| 8. Round | 27/06/2021 | Boston River | - | Liverpool | 1:1 | |
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| 9. Round | 06/07/2021 | Liverpool | - | Montevideo Wanderers | 2:1 | ||||
| 10. Round | 12/07/2021 | Rentistas | - | Liverpool | 2:1 | |
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| 14. Round | 15/08/2021 | Nacional | - | Liverpool | 1:0 |
Uruguay
Italy