| 1. Round | 25/08/2010 | River Plate | - | Defensor Sporting | 1:1 | ||||
| 2. Round | 29/08/2010 | Defensor Sporting | - | Liverpool | 3:0 |  |
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| 4. Round | 19/09/2010 | Defensor Sporting | - | Montevideo Wanderers | 1:2 | ||||
| 6. Round | 02/10/2010 | Defensor Sporting | - | Bella Vista | 1:2 | ||||
| 3. Round | 06/10/2010 | Defensor Sporting | - | CA Cerro | 2:0 | ||||
| 7. Round | 09/10/2010 | Miramar Misiones | - | Defensor Sporting | 0:1 | ||||
| 5. Round | 12/10/2010 | Defensor Sporting | - | El Tanque Sisley | 3:1 | ||||
| 8. Round | 16/10/2010 | Danubio | - | Defensor Sporting | 1:1 |  |
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| 9. Round | 24/10/2010 | Defensor Sporting | - | Rampla Juniors | 4:1 | |
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| 10. Round | 31/10/2010 | Defensor Sporting | - | Fénix | 5:1 | |
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| 11. Round | 06/11/2010 | Racing | - | Defensor Sporting | 0:3 | |
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| 12. Round | 13/11/2010 | Defensor Sporting | - | Central Español | 1:1 | ||||
| 13. Round | 20/11/2010 | Peñarol | - | Defensor Sporting | 0:1 | |
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| 14. Round | 27/11/2010 | Defensor Sporting | - | Nacional | 1:2 | ||||
| 15. Round | 05/12/2010 | Tacuarembó | - | Defensor Sporting | 1:3 | |
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