| 10. Round | 18/09/2021 | FK Druzhba | - | FK Mashuk KMV | 1:1 |  |
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| 11. Round | 26/09/2021 | Spartak Nalchik | - | FK Druzhba | 0:0 | |
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| 12. Round | 03/10/2021 | FK Druzhba | - | FK Chayka | 0:2 | |
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| 13. Round | 10/10/2021 | Anzhi Makhachkala | - | FK Druzhba | 0:0 | ||||
| 15. Round | 23/10/2021 | FK Druzhba | - | Alania-2 Vladikavkaz | 1:1 | ||||
| 16. Round | 31/10/2021 | Kuban-Holding Pavlovskaya | - | FK Druzhba | 3:1 |
Russia