| 7. Round | 10/09/2021 | FK Oleksandriya | - | Inhulets Petrove | 1:0 | ||||
| 8. Round | 18/09/2021 | Dinamo Kiev | - | FK Oleksandriya | 1:0 |  |
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| 10. Round | 03/10/2021 | NK Veres | - | FK Oleksandriya | 0:0 |  |
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| 11. Round | 17/10/2021 | FK Oleksandriya | - | Vorskla Poltava | 1:2 | ||||
| 12. Round | 22/10/2021 | Desna Chernigov | - | FK Oleksandriya | 1:1 | ||||
| 13. Round | 31/10/2021 | Rukh Lviv | - | FK Oleksandriya | 0:0 | ||||
| 14. Round | 05/11/2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 |  |
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| 15. Round | 20/11/2021 | SK Dnipro-1 | - | FK Oleksandriya | 3:1 | ||||
| 16. Round | 29/11/2021 | FK Oleksandriya | - | Zorya Lugansk | 0:1 | ||||
| 17. Round | 05/12/2021 | FK Oleksandriya | - | FC Mynai | 3:0 |
Ukraine