| 22. Round | 20/03/2022 | FK Legion Dynamo Makhachkala | - | Spartak Nalchik | 2:0 | ||||
| 23. Round | 27/03/2022 | Spartak Nalchik | - | FK Mashuk KMV | 1:3 | ||||
| 21. Round | 06/04/2022 | Spartak Nalchik | - | FK Biolog Novokubansk | 0:1 | ||||
| 25. Round | 10/04/2022 | FK Chayka | - | Spartak Nalchik | 3:0 | ||||
| 26. Round | 17/04/2022 | Spartak Nalchik | - | Anzhi Makhachkala | 3:1 | ||||
| 27. Round | 23/04/2022 | FK Druzhba | - | Spartak Nalchik | 1:0 | ||||
| 28. Round | 30/04/2022 | Spartak Nalchik | - | Alania-2 Vladikavkaz | 0:0 | ||||
| 29. Round | 06/05/2022 | Kuban-Holding Pavlovskaya | - | Spartak Nalchik | 0:3 |  |
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| 30. Round | 12/05/2022 | Spartak Nalchik | - | Forte Taganrog | 0:2 | ||||
| 31. Round | 16/05/2022 | FK Dinamo Makhachkala | - | Spartak Nalchik | 1:0 | ||||
| 32. Round | 22/05/2022 | Spartak Nalchik | - | Rotor-2 Volgograd | 2:0 |  |
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| 33. Round | 30/05/2022 | FK Tuapse | - | Spartak Nalchik | 0:4 |
Russia