| 2. Round | 02/08/2021 | Inhulets Petrove | - | Zorya Lugansk | 1:5 | ||||
| 8. Round | 19/09/2021 | Zorya Lugansk | - | Chernomorets Odessa | 3:0 | ||||
| 9. Round | 26/09/2021 | SK Dnipro-1 | - | Zorya Lugansk | 0:4 | ||||
| 10. Round | 03/10/2021 | Zorya Lugansk | - | Desna Chernigov | 2:0 |  |
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| 11. Round | 15/10/2021 | Shakhtar Donetsk | - | Zorya Lugansk | 6:1 | ||||
| 12. Round | 24/10/2021 | Zorya Lugansk | - | Kolos Kovalivka | 1:0 | ||||
| 13. Round | 31/10/2021 | Metalist 1925 Kharkiv | - | Zorya Lugansk | 1:6 | ||||
| 15. Round | 20/11/2021 | FK Lviv | - | Zorya Lugansk | 2:1 | ||||
| 18. Round | 12/12/2021 | Dinamo Kiev | - | Zorya Lugansk | 1:1 |
Ukraine