| 2. Round | 29/07/2018 | FC DAC 1904 | - | MFK Zemplín Michalovce | 4:1 | ||||
| 3. Round | 05/08/2018 | MFK Zemplín Michalovce | - | Slovan Bratislava | 1:2 |  |
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| 5. Round | 18/08/2018 | MFK Zemplín Michalovce | - | FK Senica | 1:1 |  |
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| 1. Round | 21/08/2018 | MFK Zemplín Michalovce | - | MŠK Žilina | 0:1 | ||||
| 6. Round | 25/08/2018 | Zlaté Moravce | - | MFK Zemplín Michalovce | 2:0 | ||||
| 7. Round | 01/09/2018 | MFK Zemplín Michalovce | - | FK Železiarne Podbrezová | 2:0 | ||||
| 8. Round | 15/09/2018 | ŠKF Sereď | - | MFK Zemplín Michalovce | 2:1 | |
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| 9. Round | 22/09/2018 | FC Nitra | - | MFK Zemplín Michalovce | 2:1 | ||||
| 10. Round | 29/09/2018 | MFK Zemplín Michalovce | - | MFK Ružomberok | 2:2 | ||||
| 12. Round | 20/10/2018 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:2 | ||||
| 13. Round | 27/10/2018 | MFK Zemplín Michalovce | - | FC DAC 1904 | 2:1 | |
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| 15. Round | 11/11/2018 | MFK Zemplín Michalovce | - | Spartak Trnava | 1:0 | ||||
| 16. Round | 24/11/2018 | FK Senica | - | MFK Zemplín Michalovce | 2:4 | ||||
| 19. Round | 16/02/2019 | MFK Zemplín Michalovce | - | ŠKF Sereď | 1:0 | |
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| 20. Round | 23/02/2019 | MFK Zemplín Michalovce | - | FC Nitra | 0:0 | ||||
| 22. Round | 09/03/2019 | MFK Zemplín Michalovce | - | AS Trenčín | 4:2 |
Slovakia