| 1. Round | 07/01/2023 | CF América [U20] | - | Gallos Blancos [U20] | 1:2 |  |
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| 2. Round | 14/01/2023 | Deportivo Toluca [U20] | - | CF América [U20] | 2:0 | ||||
| 3. Round | 21/01/2023 | CF América [U20] | - | Puebla FC [U20] | 2:1 | ||||
| 4. Round | 28/01/2023 | CF América [U20] | - | Mazatlán FC [U20] | 2:1 | ||||
| 5. Round | 04/02/2023 | Santos Laguna [U20] | - | CF América [U20] | 0:1 | ||||
| 8. Round | 19/02/2023 | CF América [U20] | - | Club Tijuana [U20] | 1:0 | ||||
| 10. Round | 04/03/2023 | CF América [U20] | - | CF Pachuca [U20] | 2:1 | ||||
| 11. Round | 11/03/2023 | UANL Tigres [U20] | - | CF América [U20] | 1:1 | ||||
| 12. Round | 18/03/2023 | Deportivo Guadalajara [U20] | - | CF América [U20] | 1:1 | |
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| 13. Round | 01/04/2023 | CF América [U20] | - | Club León [U20] | 2:1 | ||||
| 15. Round | 15/04/2023 | Cruz Azul [U20] | - | CF América [U20] | 1:1 | ||||
| 16. Round | 22/04/2023 | CF América [U20] | - | Pumas UNAM [U20] | 3:2 | ||||
| 17. Round | 28/04/2023 | FC Juárez [U20] | - | CF América [U20] | 2:0 |
Mexico