| 7. Round | 11/09/2021 | Metalist 1925 Kharkiv | - | Dinamo Kiev | 0:2 | ||||
| 8. Round | 19/09/2021 | FK Lviv | - | Metalist 1925 Kharkiv | 0:0 | ||||
| 9. Round | 26/09/2021 | Desna Chernigov | - | Metalist 1925 Kharkiv | 1:2 | ||||
| 10. Round | 03/10/2021 | Metalist 1925 Kharkiv | - | FC Mynai | 1:0 | ||||
| 11. Round | 16/10/2021 | FK Mariupol | - | Metalist 1925 Kharkiv | 1:2 |  |
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| 12. Round | 22/10/2021 | Metalist 1925 Kharkiv | - | Inhulets Petrove | 4:0 | ||||
| 13. Round | 31/10/2021 | Metalist 1925 Kharkiv | - | Zorya Lugansk | 1:6 | ||||
| 14. Round | 05/11/2021 | FK Oleksandriya | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 16. Round | 28/11/2021 | Rukh Lviv | - | Metalist 1925 Kharkiv | 2:0 | ||||
| 17. Round | 04/12/2021 | Metalist 1925 Kharkiv | - | Kolos Kovalivka | 0:1 |
Ukraine