| 5. Round | 28/07/2022 | Club Necaxa | - | CF Pachuca | 2:0 | ||||
| 7. Round | 08/08/2022 | CF Pachuca | - | UANL Tigres | 2:0 | ||||
| 9. Round | 18/08/2022 | CF Pachuca | - | CF América | 0:3 | ||||
| 10. Round | 22/08/2022 | CF Pachuca | - | Club León | 1:0 | ||||
| 11. Round | 28/08/2022 | Deportivo Toluca | - | CF Pachuca | 1:4 |  |
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| 8. Round | 15/09/2022 | FC Juárez | - | CF Pachuca | 2:1 | |
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| 15. Round | 19/09/2022 | Atlético San Luis | - | CF Pachuca | 1:2 |
Mexico