| 1. Round | 11/07/2022 | Club Necaxa [Women] | - | Club León [Women] | 0:2 |  |
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| 3. Round | 25/07/2022 | Club Necaxa [Women] | - | Mazatlán FC [Women] | 1:1 |  |
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| 4. Round | 30/07/2022 | UANL Tigres [Women] | - | Club Necaxa [Women] | 2:0 | ||||
| 5. Round | 01/08/2022 | Club Necaxa [Women] | - | Pumas UNAM [Women] | 2:2 | ||||
| 9. Round | 25/08/2022 | Club Necaxa [Women] | - | Puebla FC [Women] | 3:3 |  |
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| 11. Round | 12/09/2022 | Club Necaxa [Women] | - | CF Pachuca [Women] | 0:1 | ||||
| 12. Round | 19/09/2022 | Deportivo Toluca [Women] | - | Club Necaxa [Women] | 2:1 | ||||
| 13. Round | 22/09/2022 | Club Necaxa [Women] | - | Santos Laguna [Women] | 1:1 | ||||
| 14. Round | 27/09/2022 | FC Juárez [Women] | - | Club Necaxa [Women] | 3:0 | ||||
| 15. Round | 02/10/2022 | Club Necaxa [Women] | - | Atlas Guadalajara [Women] | 0:2 | ||||
| 16. Round | 18/10/2022 | Club Tijuana [Women] | - | Club Necaxa [Women] | 1:1 | ||||
| 17. Round | 24/10/2022 | Club Necaxa [Women] | - | Atlético San Luis [Women] | 0:2 | |
Mexico