| 3. Round | 08/08/2020 | Deportivo Guadalajara [U20] | - | Puebla FC [U20] | 0:0 |  |
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| 5. Round | 15/08/2020 | Deportivo Guadalajara [U20] | - | Atlético San Luis [U20] | 7:1 |  |
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| 6. Round | 23/08/2020 | Deportivo Toluca [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 7. Round | 29/08/2020 | Deportivo Guadalajara [U20] | - | CF Pachuca [U20] | 3:2 | ||||
| 8. Round | 05/09/2020 | UANL Tigres [U20] | - | Deportivo Guadalajara [U20] | 0:1 | ||||
| 9. Round | 08/09/2020 | Deportivo Guadalajara [U20] | - | Gallos Blancos [U20] | 3:1 | ||||
| 11. Round | 19/09/2020 | CF América [U20] | - | Deportivo Guadalajara [U20] | 1:2 | |
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| 12. Round | 26/09/2020 | Deportivo Guadalajara [U20] | - | Mazatlán FC [U20] | 3:1 | |
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| 13. Round | 04/10/2020 | Club Tijuana [U20] | - | Deportivo Guadalajara [U20] | 0:3 | ||||
| 4. Round | 07/10/2020 | FC Juárez [U20] | - | Deportivo Guadalajara [U20] | 2:1 | |
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| 1. Round | 11/10/2020 | Deportivo Guadalajara [U20] | - | Club León [U20] | 3:1 | ||||
| 2. Round | 13/11/2020 | Santos Laguna [U20] | - | Deportivo Guadalajara [U20] | 2:2 | |
Mexico