| 19. Round | 03/02/2019 | Club Irapuato | - | Cruz Azul Hidalgo | 1:0 |  |
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| 20. Round | 09/02/2019 | Cocodrilos de Tabasco | - | Club Irapuato | 1:0 | ||||
| 21. Round | 17/02/2019 | Club Irapuato | - | Real Zamora | 3:0 | ||||
| 22. Round | 23/02/2019 | Sporting Canamy | - | Club Irapuato | 1:3 | ||||
| 24. Round | 10/03/2019 | Club Irapuato | - | Tuxtla FC | 2:0 | ||||
| 25. Round | 16/03/2019 | Inter Playa | - | Club Irapuato | 0:0 | ||||
| 26. Round | 24/03/2019 | Club Irapuato | - | CF América II | 5:0 | |
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| 27. Round | 29/03/2019 | Pumas UNAM II | - | Club Irapuato | 3:2 |
Mexico