| 1. Round | 24/07/2021 | CF Pachuca [U20] | - | Club León [U20] | 0:1 | ||||
| 2. Round | 31/07/2021 | Club León [U20] | - | Club Tijuana [U20] | 2:1 | ||||
| 3. Round | 05/08/2021 | Gallos Blancos [U20] | - | Club León [U20] | 1:0 | ||||
| 4. Round | 14/08/2021 | Club León [U20] | - | Mazatlán FC [U20] | 1:0 | ||||
| 5. Round | 18/08/2021 | Deportivo Guadalajara [U20] | - | Club León [U20] | 1:2 |  |
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| 6. Round | 21/08/2021 | Club León [U20] | - | Santos Laguna [U20] | 1:1 | ||||
| 7. Round | 28/08/2021 | Club León [U20] | - | CF América [U20] | 2:2 | ||||
| 8. Round | 11/09/2021 | UANL Tigres [U20] | - | Club León [U20] | 2:0 | ||||
| 9. Round | 18/09/2021 | Club León [U20] | - | FC Juárez [U20] | 2:0 | ||||
| 10. Round | 25/09/2021 | Atlas Guadalajara [U20] | - | Club León [U20] | 2:1 |  |
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| 12. Round | 02/10/2021 | Club León [U20] | - | Atlético San Luis [U20] | 2:0 |
Mexico