| 4. Round | 10/08/2021 | FC Juárez [Women] | - | Deportivo Guadalajara [Women] | 1:2 | ||||
| 5. Round | 15/08/2021 | Deportivo Guadalajara [Women] | - | Club Necaxa [Women] | 6:0 | ||||
| 7. Round | 29/08/2021 | Deportivo Guadalajara [Women] | - | Mazatlán FC [Women] | 2:0 | ||||
| 11. Round | 02/10/2021 | Pumas UNAM [Women] | - | Deportivo Guadalajara [Women] | 1:0 | ||||
| 12. Round | 12/10/2021 | Deportivo Guadalajara [Women] | - | CF América [Women] | 2:1 | ||||
| 13. Round | 19/10/2021 | Deportivo Guadalajara [Women] | - | UANL Tigres [Women] | 1:1 | ||||
| 14. Round | 31/10/2021 | Puebla FC [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 15. Round | 07/11/2021 | Deportivo Guadalajara [Women] | - | Gallos Blancos [Women] | 0:2 |
Mexico