| 1. Round | 05/07/2024 | Puebla FC | - | Santos Laguna | 1:0 | ||||
| 2. Round | 14/07/2024 | Santos Laguna | - | Pumas UNAM | 1:1 | ||||
| 3. Round | 17/07/2024 | Atlas Guadalajara | - | Santos Laguna | 1:0 | ||||
| 8. Round | 19/08/2024 | Club Tijuana | - | Santos Laguna | 3:1 | ||||
| 5. Round | 25/08/2024 | Club León | - | Santos Laguna | 1:1 |  |
|||
| 9. Round | 23/09/2024 | Santos Laguna | - | Deportivo Toluca | 2:0 | ||||
| 10. Round | 29/09/2024 | Atlético San Luis | - | Santos Laguna | 3:1 | ||||
| 12. Round | 20/10/2024 | CF América | - | Santos Laguna | 3:0 |  |
|||
| 15. Round | 03/11/2024 | Cruz Azul | - | Santos Laguna | 2:0 | ||||
| 16. Round | 06/11/2024 | Santos Laguna | - | Deportivo Guadalajara | 0:2 |
Mexico