| 7. Round | 07/08/2022 | Orlando City | - | New England Revolution | 0:3 | ||||
| 7. Round | 29/08/2022 | Orlando City | - | New York City FC | 2:1 | ||||
| 7. Round | 01/09/2022 | Orlando City | - | Seattle Sounders | 3:2 | ||||
| 8. Round | 11/09/2022 | Philadelphia Union | - | Orlando City | 5:1 | ||||
| 8. Round | 14/09/2022 | Orlando City | - | Atlanta United FC | 0:1 | ||||
| 8. Round | 18/09/2022 | Orlando City | - | Toronto FC | 4:0 | ||||
| 9. Round | 02/10/2022 | New York City FC | - | Orlando City | 2:1 | ||||
| 9. Round | 06/10/2022 | Inter Miami CF | - | Orlando City | 4:1 | ||||
| 9. Round | 09/10/2022 | Orlando City | - | Columbus Crew | 2:1 |  |
Colombia