| 1. Round | 19/07/2021 | Libertad | - | Guaireña FC | 0:0 | ||||
| 4. Round | 07/08/2021 | Club Nacional | - | Libertad | 1:0 | ||||
| 5. Round | 16/08/2021 | Libertad | - | 12 de Octubre de Itauguá | 3:3 |  |
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| 6. Round | 24/08/2021 | Guaraní | - | Libertad | 2:2 | ||||
| 8. Round | 13/09/2021 | Libertad | - | Club Olimpia | 0:3 | ||||
| 9. Round | 18/09/2021 | River Plate | - | Libertad | 0:1 | ||||
| 13. Round | 25/10/2021 | Libertad | - | Club Nacional | 1:2 | ||||
| 14. Round | 30/10/2021 | 12 de Octubre de Itauguá | - | Libertad | 0:1 | ||||
| 15. Round | 07/11/2021 | Libertad | - | Guaraní | 2:0 |
Paraguay