| 1. Round | 31/07/2012 | Cerro Porteño | - | Guaraní | 1:2 |  |
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| 2. Round | 04/08/2012 | Guaraní | - | Independiente CG | 3:1 |  |
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| 3. Round | 12/08/2012 | Libertad | - | Guaraní | 0:0 | ||||
| 4. Round | 19/08/2012 | Guaraní | - | Sportivo Luqueño | 1:0 | |
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| 5. Round | 25/08/2012 | Club Nacional | - | Guaraní | 1:2 | ||||
| 7. Round | 02/09/2012 | Cerro de Franco | - | Guaraní | 1:0 | ||||
| 6. Round | 09/09/2012 | Guaraní | - | Tacuary | 2:0 | |
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| 8. Round | 15/09/2012 | Club Olimpia | - | Guaraní | 0:1 | |
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| 9. Round | 25/09/2012 | Guaraní | - | Sol de América | 3:2 | |
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| 10. Round | 30/09/2012 | Sportivo Carapeguá | - | Guaraní | 1:2 | ||||
| 11. Round | 07/10/2012 | Guaraní | - | Club Rubio Ñu | 2:0 | ||||
| 12. Round | 19/10/2012 | Guaraní | - | Cerro Porteño | 2:1 | |
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| 22. Round | 16/12/2012 | Club Rubio Ñu | - | Guaraní | 1:0 |
Paraguay