| 1. Round | 23/01/2016 | Club Nacional | - | Guaraní | 2:1 |  |
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| 4. Round | 07/02/2016 | Guaraní | - | Cerro Porteño | 0:0 | ||||
| 5. Round | 14/02/2016 | Sportivo Luqueño | - | Guaraní | 1:2 | ||||
| 6. Round | 21/02/2016 | Guaraní | - | General Caballero ZC | 1:2 | ||||
| 7. Round | 27/02/2016 | River Plate | - | Guaraní | 1:1 | ||||
| 8. Round | 01/03/2016 | Club Rubio Ñu | - | Guaraní | 2:2 |  |
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| 10. Round | 13/03/2016 | Sol de América | - | Guaraní | 0:0 | ||||
| 11. Round | 20/03/2016 | Guaraní | - | Libertad | 1:3 | |
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| 3. Round | 26/03/2016 | General Díaz | - | Guaraní | 3:2 | |
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| 12. Round | 02/04/2016 | Guaraní | - | Club Nacional | 1:0 | |
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| 13. Round | 06/04/2016 | Deportivo Capiatá | - | Guaraní | 0:2 | |
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| 15. Round | 18/04/2016 | Cerro Porteño | - | Guaraní | 3:4 | |
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| 16. Round | 22/04/2016 | Guaraní | - | Sportivo Luqueño | 3:2 | ||||
| 18. Round | 30/04/2016 | Guaraní | - | River Plate | 4:2 | |
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| 19. Round | 05/05/2016 | Guaraní | - | Club Rubio Ñu | 3:1 | ||||
| 20. Round | 10/05/2016 | Club Olimpia | - | Guaraní | 3:2 | ||||
| 22. Round | 21/05/2016 | Libertad | - | Guaraní | 0:0 | |
Paraguay