| 5. Round | 04/03/2022 | San Lorenzo II | - | River Plate II | 0:4 | ||||
| 6. Round | 12/03/2022 | Talleres de Córdoba II | - | San Lorenzo II | 2:3 |  |
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| 7. Round | 21/03/2022 | San Lorenzo II | - | Huracán II | 0:0 | ||||
| 8. Round | 04/04/2022 | San Lorenzo II | - | Atlético Tucumán II | 1:1 | ||||
| 9. Round | 10/04/2022 | Sarmiento de Junín II | - | San Lorenzo II | 1:2 | ||||
| 11. Round | 20/04/2022 | Unión de Santa Fe II | - | San Lorenzo II | 1:4 | ||||
| 12. Round | 24/04/2022 | San Lorenzo II | - | Patronato de Paraná II | 3:0 | |
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| 13. Round | 30/04/2022 | Newell's Old Boys II | - | San Lorenzo II | 0:3 | ||||
| 14. Round | 09/05/2022 | San Lorenzo II | - | Racing Club II | 3:1 | |
Paraguay
Argentina