| 1. Round | 24/07/2021 | FK Yessentuki | - | FK Biolog Novokubansk | 0:5 | ||||
| 3. Round | 07/08/2021 | FK Biolog Novokubansk | - | FK Legion Dynamo Makhachkala | 0:0 | ||||
| 5. Round | 18/08/2021 | FK Biolog Novokubansk | - | Spartak Nalchik | 1:0 |  |
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| 8. Round | 08/09/2021 | FK Druzhba | - | FK Biolog Novokubansk | 1:1 | ||||
| 10. Round | 18/09/2021 | Kuban-Holding Pavlovskaya | - | FK Biolog Novokubansk | 2:1 | |
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| 11. Round | 26/09/2021 | FK Biolog Novokubansk | - | Forte Taganrog | 0:0 | ||||
| 12. Round | 03/10/2021 | FK Dinamo Makhachkala | - | FK Biolog Novokubansk | 2:0 | ||||
| 13. Round | 10/10/2021 | FK Biolog Novokubansk | - | Rotor-2 Volgograd | 3:0 | |
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| 14. Round | 18/10/2021 | FK Tuapse | - | FK Biolog Novokubansk | 0:3 dec. | |
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| 15. Round | 23/10/2021 | FK Biolog Novokubansk | - | FK SKA Rostov | 1:3 | |
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| 16. Round | 31/10/2021 | Dinamo Stavropol | - | FK Biolog Novokubansk | 1:0 | ||||
| 17. Round | 06/11/2021 | FK Biolog Novokubansk | - | Chernomorets Novorossisk | 2:2 | |
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| 19. Round | 20/11/2021 | FK Legion Dynamo Makhachkala | - | FK Biolog Novokubansk | 1:0 |
Russia