| 1. Round | 25/07/2021 | Krylia Sovetov | - | Akhmat Grozny | 1:2 | ||||
| 2. Round | 30/07/2021 | Krylia Sovetov | - | Spartak Moskva | 0:1 | ||||
| 3. Round | 07/08/2021 | Arsenal Tula | - | Krylia Sovetov | 2:1 |  |
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| 4. Round | 15/08/2021 | Rubin Kazan | - | Krylia Sovetov | 1:1 | |
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| 5. Round | 21/08/2021 | Krylia Sovetov | - | FK Sochi | 1:0 | |
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| 6. Round | 26/08/2021 | FK Ufa | - | Krylia Sovetov | 1:2 | ||||
| 7. Round | 11/09/2021 | Lokomotiv Moskva | - | Krylia Sovetov | 2:0 | ||||
| 8. Round | 18/09/2021 | Krylia Sovetov | - | FK Rostov | 4:2 | ||||
| 9. Round | 25/09/2021 | Zenit St. Petersburg | - | Krylia Sovetov | 2:1 |  |
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| 10. Round | 02/10/2021 | Dinamo Moskva | - | Krylia Sovetov | 0:1 | ||||
| 11. Round | 17/10/2021 | Krylia Sovetov | - | FK Nizhny Novgorod | 2:0 | ||||
| 12. Round | 23/10/2021 | CSKA Moskva | - | Krylia Sovetov | 3:1 | |
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| 13. Round | 30/10/2021 | FK Krasnodar | - | Krylia Sovetov | 0:1 | |
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| 14. Round | 06/11/2021 | Krylia Sovetov | - | FK Khimki | 3:0 | |
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| 15. Round | 20/11/2021 | Krylia Sovetov | - | FK Ural | 1:1 | ||||
| 16. Round | 28/11/2021 | FK Nizhny Novgorod | - | Krylia Sovetov | 0:0 | ||||
| 17. Round | 04/12/2021 | Krylia Sovetov | - | CSKA Moskva | 0:1 | ||||
| 18. Round | 11/12/2021 | Krylia Sovetov | - | Rubin Kazan | 2:0 | |
Russia