| 2. Round | 26/01/2019 | Club Olimpia | - | San Lorenzo | 2:0 | ||||
| 3. Round | 03/02/2019 | Sportivo Luqueño | - | Club Olimpia | 1:5 |  |
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| 5. Round | 09/02/2019 | Sol de América | - | Club Olimpia | 0:1 | ||||
| 6. Round | 17/02/2019 | Club Olimpia | - | Cerro Porteño | 2:2 | ||||
| 7. Round | 24/02/2019 | Libertad | - | Club Olimpia | 2:3 | ||||
| 11. Round | 17/03/2019 | Guaraní | - | Club Olimpia | 1:5 | ||||
| 12. Round | 24/03/2019 | Club Olimpia | - | Club Nacional | 0:0 | ||||
| 16. Round | 13/04/2019 | Club Olimpia | - | Sol de América | 4:0 | ||||
| 14. Round | 17/04/2019 | Club Olimpia | - | Sportivo Luqueño | 2:0 | ||||
| 18. Round | 28/04/2019 | Club Olimpia | - | Libertad | 3:0 | ||||
| 19. Round | 01/05/2019 | Deportivo Capiatá | - | Club Olimpia | 2:2 | ||||
| 21. Round | 14/05/2019 | River Plate | - | Club Olimpia | 2:2 | ||||
| 22. Round | 18/05/2019 | Club Olimpia | - | Guaraní | 2:0 |
Paraguay