| 2. Round | 27/07/2021 | 12 de Octubre de Itauguá | - | Club Olimpia | 1:3 | ||||
| 3. Round | 02/08/2021 | Club Olimpia | - | Guaireña FC | 0:2 |  |
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| 4. Round | 07/08/2021 | Guaraní | - | Club Olimpia | 3:1 | ||||
| 5. Round | 14/08/2021 | Club Olimpia | - | Cerro Porteño | 0:3 |  |
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| 8. Round | 13/09/2021 | Libertad | - | Club Olimpia | 0:3 | ||||
| 9. Round | 21/09/2021 | Club Olimpia | - | Club Nacional | 1:2 | ||||
| 10. Round | 26/09/2021 | River Plate | - | Club Olimpia | 1:2 | ||||
| 11. Round | 02/10/2021 | Club Olimpia | - | 12 de Octubre de Itauguá | 1:2 | ||||
| 12. Round | 18/10/2021 | Guaireña FC | - | Club Olimpia | 0:2 | ||||
| 13. Round | 24/10/2021 | Club Olimpia | - | Guaraní | 1:3 | ||||
| 17. Round | 26/11/2021 | Club Olimpia | - | Libertad | 2:3 | |
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| 18. Round | 05/12/2021 | Club Nacional | - | Club Olimpia | 1:3 |
Paraguay