| 2. Round | 12/02/2022 | Guaireña FC | - | Club Olimpia | 1:3 |  |
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| 3. Round | 20/02/2022 | Club Olimpia | - | Libertad | 2:2 | ||||
| 6. Round | 13/03/2022 | Cerro Porteño | - | Club Olimpia | 0:2 | ||||
| 7. Round | 20/03/2022 | Club Olimpia | - | Sportivo Ameliano | 0:2 | |
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| 8. Round | 02/04/2022 | Resistencia SC | - | Club Olimpia | 2:1 | |
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| 12. Round | 24/04/2022 | General Caballero DJLM | - | Club Olimpia | 2:3 | |
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| 13. Round | 02/05/2022 | Club Olimpia | - | Guaireña FC | 1:0 | |
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| 15. Round | 11/05/2022 | Club Olimpia | - | Sol de América | 1:0 | ||||
| 19. Round | 19/06/2022 | Club Olimpia | - | Resistencia SC | 6:1 |  |
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| 20. Round | 23/06/2022 | Club Nacional | - | Club Olimpia | 1:1 | ||||
| 21. Round | 26/06/2022 | Club Olimpia | - | 12 de Octubre de Itauguá | 4:1 | |
Paraguay