2. Round | 03/02/2023 | Tacuary | - | Guaireña FC | 1:2 | ||||
3. Round | 12/02/2023 | Guaireña FC | - | Sportivo Trinidense | 1:1 | ||||
4. Round | 17/02/2023 | Guaireña FC | - | Cerro Porteño | 0:2 | ||||
5. Round | 26/02/2023 | Club Olimpia | - | Guaireña FC | 1:1 | ||||
12. Round | 12/04/2023 | Club Nacional | - | Guaireña FC | 2:2 | ||||
14. Round | 22/04/2023 | Sportivo Trinidense | - | Guaireña FC | 1:0 | ||||
15. Round | 28/04/2023 | Cerro Porteño | - | Guaireña FC | 2:0 | ||||
16. Round | 08/05/2023 | Guaireña FC | - | Club Olimpia | 1:0 | ||||
17. Round | 12/05/2023 | General Caballero DJLM | - | Guaireña FC | 3:0 | ||||
18. Round | 16/05/2023 | Guaireña FC | - | Libertad | 0:2 | ||||
19. Round | 22/05/2023 | Sportivo Ameliano | - | Guaireña FC | 1:1 | ||||
20. Round | 29/05/2023 | Guaireña FC | - | Guaraní | 2:2 | ||||
21. Round | 04/06/2023 | Resistencia SC | - | Guaireña FC | 0:2 |