| 2. Round | 10/01/2025 | Santos Laguna [Women] | - | Deportivo Guadalajara [Women] | 0:1 | ||||
| 4. Round | 21/01/2025 | Cruz Azul [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 5. Round | 26/01/2025 | Deportivo Guadalajara [Women] | - | CF Monterrey [Women] | 0:1 | ||||
| 6. Round | 03/02/2025 | Mazatlán FC [Women] | - | Deportivo Guadalajara [Women] | 0:8 |  |
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| 7. Round | 07/02/2025 | Deportivo Guadalajara [Women] | - | Atlético San Luis [Women] | 3:1 | ||||
| 8. Round | 11/02/2025 | Club Tijuana [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 9. Round | 14/02/2025 | Deportivo Guadalajara [Women] | - | Deportivo Toluca [Women] | 1:0 | ||||
| 10. Round | 04/03/2025 | UANL Tigres [Women] | - | Deportivo Guadalajara [Women] | 2:0 | ||||
| 11. Round | 08/03/2025 | Deportivo Guadalajara [Women] | - | CF América [Women] | 1:1 | ||||
| 12. Round | 13/03/2025 | Gallos Blancos [Women] | - | Deportivo Guadalajara [Women] | 1:1 | ||||
| 16. Round | 14/04/2025 | CF Pachuca [Women] | - | Deportivo Guadalajara [Women] | 1:0 | ||||
| 17. Round | 18/04/2025 | Deportivo Guadalajara [Women] | - | Pumas UNAM [Women] | 0:0 |
Mexico