| 1. Round | 08/01/2022 | Cruz Azul [U18] | - | Club Tijuana [U18] | 3:2 |  |
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| 2. Round | 15/01/2022 | Club Tijuana [U18] | - | Club León [U18] | 1:2 | ||||
| 3. Round | 21/01/2022 | Puebla FC [U18] | - | Club Tijuana [U18] | 1:1 | ||||
| 5. Round | 11/02/2022 | Mazatlán FC [U18] | - | Club Tijuana [U18] | 0:2 | ||||
| 6. Round | 18/02/2022 | Club Tijuana [U18] | - | Club Necaxa [U18] | 3:2 |
Mexico