| 1. Round | 13/01/2021 | Pumas Tabasco | - | Tapatío | 0:1 | ||||
| 2. Round | 21/01/2021 | Club Celaya | - | Pumas Tabasco | 2:1 |  |
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| 3. Round | 27/01/2021 | Mineros de Zacatecas | - | Pumas Tabasco | 1:2 | ||||
| 5. Round | 09/02/2021 | Alebrijes de Oaxaca | - | Pumas Tabasco | 3:1 | ||||
| 6. Round | 17/02/2021 | Pumas Tabasco | - | Cimarrones de Sonora | 0:0 | ||||
| 7. Round | 26/02/2021 | Tepatitlán | - | Pumas Tabasco | 1:2 | ||||
| 8. Round | 04/03/2021 | Pumas Tabasco | - | Atlético Morelia | 0:1 | ||||
| 9. Round | 10/03/2021 | Dorados de Sinaloa | - | Pumas Tabasco | 1:1 | ||||
| 10. Round | 17/03/2021 | Pumas Tabasco | - | TM Fútbol Club | 0:0 | ||||
| 14. Round | 11/04/2021 | Atlante | - | Pumas Tabasco | 1:0 | ||||
| 15. Round | 15/04/2021 | Pumas Tabasco | - | Cancún FC | 1:2 |
Mexico